Adenosylmethionine Elevation in Leukemic White Blood Cells

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Science  06 Aug 1965:
Vol. 149, Issue 3684, pp. 644-645
DOI: 10.1126/science.149.3684.644


White blood cell preparations from patients with chronic myelocytic leukemia have more S-adenosylmethionine, an important metabolic intermediate, than normal peripheral white cells or thoracic-duct lymphocytes. The previously reported elevation of cyanocobalamine (vitamin Bl2) in the serum of patients with this disease is corroborated. The possible usefulness of methylation antimetabolites in cancer chemotherapy is suggested.