Renin Production by Organ Cultures of Renal Cortex

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Science  06 Aug 1965:
Vol. 149, Issue 3684, pp. 650-651
DOI: 10.1126/science.149.3684.650


Diploid cells of the human and canine renal cortex can be isolated by newly developed techniques for organ culture. Some of these cells have abundant Bowie's positive granules. Bioassays for renin activity have shown that these granular cells can synthesize considerable amounts of renin in vitro. These investigations provide a model for studying the production of renin at cellular level.