Metabolism of Iodine-131-Labeled Thyroxine-Binding Prealbumin in Man

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Science  13 Aug 1965:
Vol. 149, Issue 3685, pp. 748-750
DOI: 10.1126/science.149.3685.748


The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 daysin normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.