Transformation by Rous Sarcoma Virus: A Requirement for DNA Synthesis

See allHide authors and affiliations

Science  13 Aug 1965:
Vol. 149, Issue 3685, pp. 757-758
DOI: 10.1126/science.149.3685.757


Transient inhibition of DNA synthesis immediately after infection of cells with Rous sarcoma virus prevents subsequent morphological transformationof the cells. Inhibition of DNA synthesis for an identical period before infection, or later in the course of infection, has only slight effect on transformation. Thus DNA synthesis is a specific requirement in the transformation of cells by Rous sarcoma virus.