Primary Immune Reactions in Organ Cultures

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Science  27 Aug 1965:
Vol. 149, Issue 3687, pp. 991-993
DOI: 10.1126/science.149.3687.991


Primary immune reactions were initiated and maintained in vitro. Spleen explants from mice treated with either phytohemagglutinin or adjuvant were stimulated to form hemagglutinins and hemolysins, whereas no treatment of spleen donors was necessary to invoke a "graft-versus-host" response which led to specific splenomegly.