Inhibition of L1210 Tumor Growth by Thymus DNA

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Science  27 Aug 1965:
Vol. 149, Issue 3687, pp. 997-998
DOI: 10.1126/science.149.3687.997


Growth of L1210 leukemia cells which had been previously incubated with thymus DNA was inhibited. Leukemia-cell DNA did not affect tumor growth under similar conditions. Pretreatment of the thymus DNA with deoxyribonuclease suppressed the DNA induced inhibition. Both ribonucleasetreated DNA and untreated DNA inhibited tumor growth.