Immunoglobulin Structure: Partial Amino Acid Sequence of a Bence Jones Protein

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Science  03 Sep 1965:
Vol. 149, Issue 3688, pp. 1090-1092
DOI: 10.1126/science.149.3688.1090


Sequence analysis and ordering of the soluble tryptic peptides of one Bence Jones protein and comparison with partial sequence data for another have revealed many structural differences in the half of the molecule with the terminal amino group, but only one structural difference in the half of the molecule having the terminal carboxyl group. Somatic chromosomal rearrangements may effect such changes and account for variability in antibody structure.

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