Turnover of Ribosomal RNA in Rat Liver

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Science  03 Sep 1965:
Vol. 149, Issue 3688, pp. 1093-1095
DOI: 10.1126/science.149.3688.1093


After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about S days. The possible significance of this result is discussed with regard to control of protein synthesis.