Protein Synthesis by Ribosomes from Heart Muscle: Effect of Insulin and Diabetes

Science  03 Sep 1965:
Vol. 149, Issue 3688, pp. 1102-1103
DOI: 10.1126/science.149.3688.1102


Incorporation of phenylalanine into protein by ribosomes from the heart muscle of rats is decreased when the ribosomes are from alloxan-diabetic animals. Protein synthesis is increased when the ribosomes are obtained from nondiabetic animals I hour after treatment with insulin. The change due to insulin appears to be an alteration in the function of the ribosome.