Anomalous Dispersion Method: Its Power for Protein Structure Analysis

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Science  08 Oct 1965:
Vol. 150, Issue 3693, pp. 212-214
DOI: 10.1126/science.150.3693.212


The phases of x-ray reflection of a crystal can be measured, except for an ambiguity, if the crystal contains heavy atoms which scatter x-rays anomalously. Theoretical studies show that the method of resolving this ambiguity by choosing the phases closer to those of the heavy atoms has a good potentiality for solving complicated structures, in which the average heavy atom contribution to the intensity is as low as 10 percent.