Reports

Hemolysin of Mycoplasma pneumoniae: Tentative Identification as a Peroxide

See allHide authors and affiliations

Science  08 Oct 1965:
Vol. 150, Issue 3693, pp. 226-228
DOI: 10.1126/science.150.3693.226

Abstract

Mycoplasma pneumoniae produces a soluble hemolysin active against guinea pig erythrocytes. This hemolysin appears to be a peroxide, since catalase or peroxidase inhibits its activity. The action of catalase and peroxidase is specific, since heating the enzymes abolishes their effect on the hemolysin. In addition, 3-amino- 1,2,4-triazole, a potent inhibitor of catalase, reverses the inhibitory effect of the enzyme. The hemolysin of M. laidlawii is also a peroxide. The hemolysins of M. pneumoniae and M. laidlawii seem unique for microbial organisms since the bacterial hemolysins which have been described have been protein or lipid in nature.