Wasting Disease Induced with Cortisol Acetate: Studies in Germ-Free Mice

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Science  15 Oct 1965:
Vol. 150, Issue 3694, pp. 356-357
DOI: 10.1126/science.150.3694.356


A marked difference in mortality was observed between germ-free mice and conventionally reared mice, both given a single injection of cortisol acetate. The incidence of death in germ-free mice was significantly lower than in conventionally reared mice. Mortality in germ-free mice treated with cortisol acetate was in creased by monocontamination with Escherichia coli.