Hybridization Experiments: Evidence of Dissociation Equilibrium in Hemerythrin

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Science  15 Oct 1965:
Vol. 150, Issue 3694, pp. 357-359
DOI: 10.1126/science.150.3694.357


Partial succinylation of hemerythrin alters its electrophoretic mobility even though it remains an octameric macromolecule. Mixtures of this modified protein and unmodified hemerythrin generate species of intermediate electrophoretic mobility. Such behavior provides strong evidence that the octameric macromolecule is in mobile equilibrium with monomeric subunits.