Delta-Aminolevulinate Dehydratase Activity in Mice with Hereditary Anemia

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Science  22 Oct 1965:
Vol. 150, Issue 3695, pp. 496-497
DOI: 10.1126/science.150.3695.496


Homozygous (f/f) but not heterozygous (f/+) mice of the highly congenic strain, FL/ Re, manifest a severe transitory siderocytic fetal anemia. Adults of both f/f and f/+ genotype manifest decreased hepatic, splenic, and renal levels of ▵-amino-levulinate dehydratase (ALD) activity compared to homozygous (+/+) mice of the same strain. The degree of augmentation in splenic ALD activity following phenylhydrazine administration is high in +/+, intermediate in f/+, and low in f/f mice. These findings suggest that perhaps a deficiency in the fetal level of ALD may be responsible for the transitory fetal anemia.