Soluble Proteins of a Melanoma and Normal Skin from the Swordtail, Platyfish, and Their Hybrids

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Science  29 Oct 1965:
Vol. 150, Issue 3696, pp. 635-636
DOI: 10.1126/science.150.3696.635


Acrylamide gel electrophoresis has been used to make comparisons of the distribution of soluble protein and the activity of esterase in skin and melanoma extracts of the swordtail, the platyfish, and their hybrids. There is a striking difference between the extracts of normal skin and tumor tissue derived from the same cytological elements. Several prominent protein bands are found only in the tumor tissue. Their origin and function are unknown.