Uptake as a Determinant of Methotrexate Response in Mouse Leukemias

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Science  05 Nov 1965:
Vol. 150, Issue 3697, pp. 752-754
DOI: 10.1126/science.150.3697.752


Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r2 = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.