Recombination in Bacteriophage T4: a Mechanism

Science  05 Nov 1965:
Vol. 150, Issue 3697, pp. 760-763
DOI: 10.1126/science.150.3697.760


Genetic recombination between rIl mutants of T4 bacteriophage grown in Escherichia coli can occur under conditions where DNA synthesis is strongly inhibited by 5-fluorodeoxyuridine. The small amount of DNA synthesized under these conditions cannot account for the observed frequency of recombinants. The major mechanism of recombination in this system is a process of breakage and rejoining.