Histamine Synthesis and Gastric Secretion after Portacaval Shunt

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Science  19 Nov 1965:
Vol. 150, Issue 3699, pp. 1034-1035
DOI: 10.1126/science.150.3699.1034


In man there is an increased incidence of peptic ulcer after portacaval shunt. In the rat, 2 months after portacaval anastomosis, there is a generalized increase in the histamine content of the soft tissues, and the increase is most marked in the acid-secreting portion of the stomach. This appears to be secondary to increased activity of the histamine-synthesizing enzyme, histidine decarboxylase. A histidine decarboxylase inhibitor can prevent such hypersecretion of acid in the stomach of these animals.