Phenylketonuria: Limit in Capacity of Pre-Weanling Rats To Oxidize β-Phenyllactate and Other α-Hydroxy Acids

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Science  19 Nov 1965:
Vol. 150, Issue 3699, pp. 1042-1044
DOI: 10.1126/science.150.3699.1042


In comparison with mature animals, pre-weanling rats have markedly higher and longer lasting serum levels of β-phenyllactate following the intraperitoneal injection of a moderate dose. A corresponding age-dependent difference in the rate of oxidation of β-phenyllactate and other α-hydroxy acids was observed in experiments with homogenates and supernatant fractions of rat kidney.