Oncogenicity of the Simian Adenoviruses

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Science  19 Nov 1965:
Vol. 150, Issue 3699, pp. 1044-1046
DOI: 10.1126/science.150.3699.1044


Five of 17 adenoviruses of rhesus or cynomolgus monkey origin induced tumors in newborn hamsters. The tumors appeared between 42 and 280 days after subcutaneous inoculation and had the general characteristics of lymphomas. The tumors were specific by cross-complement fixation tests. An adenovirus recovered from Cercopithecus monkeys appeared to be highly oncogenic; all 23 inoculated hamsters developed tumors within 30 to 40 days.