Rabbit 19S Antibodies with Allotypic Specificities of the a-Locus Group

Science  03 Dec 1965:
Vol. 150, Issue 3701, pp. 1298-1303
DOI: 10.1126/science.150.3701.1298


Activity of bacteriophage T4 neutralizing antiserums obtained 8 days after a primary immunization of rabbits with purified phage T4 is due to antibodies of the 19S (IgM) type. This neutralizing activity could be partially inhibited by treatment with excess antiserum directed against the a-locus group allotypic specificity carried by the whole rabbit serum.