Adrenaline Synthesis: Control by the Pituitary Gland and Adrenal Glucocorticoids

See allHide authors and affiliations

Science  10 Dec 1965:
Vol. 150, Issue 3702, pp. 1464-1465
DOI: 10.1126/science.150.3702.1464


The activity of phenylethanolamine-N-methyl transferase, an enzyme that synthesizes adrenaline from noradrenaline in the adrenal medulla, is markedly depressed following hypophysectomy. Enzyme activity is restored to normal after administration of ACTH or the potent glucocorticoid, dexamethasone. Thus the biosynthesis of adrenaline in the adrenal medulla appears to be regulated by the pituitary-adrenocortical system.