Biosynthesis of Histones and Acidic Nuclear Proteins under Different Conditions of Growth

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Science  10 Dec 1965:
Vol. 150, Issue 3702, pp. 1470-1472
DOI: 10.1126/science.150.3702.1470


The incorporation of uniformly labeled L-lysine-C14 into the normal and regenerating rat liver, into Novikoff hepatoma histones, and into acidic nuclear proteins was studied. In rat liver, different histone fractions incorporate labeled lysine to a different extent. Such differences become less obvious in regenerating liver, and they are even less so in Novikoff hepatoma. In the hepatoma cells the ratio of the biosynthesized acidic nuclear proteins to histones was altered.