X-Linked 6-Phosphogluconate Dehydrogenase in Drosophila: Subunit Associations

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Science  17 Dec 1965:
Vol. 150, Issue 3703, pp. 1601-1602
DOI: 10.1126/science.150.3703.1601


6-Phosphogluconate dehydrogenase (PGD) subunits have been dissociated and reassociated in vitro. The intermediate PGD of the heterozygous phenotype is reproduced by reassociation in vitro of subunits derived from the two types of PGD from homozygous flies. This result has a bearingon gene action in the diploid organism and on the mechanism of dosage compensation in Drosophila melanogaster.