Steroid Stimulation of Beating of Cultured Rat-Heart Cells

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Science  17 Dec 1965:
Vol. 150, Issue 3703, pp. 1611-1613
DOI: 10.1126/science.150.3703.1611


The addition of cortisol acetate and deoxycorticosterone acetate to cultured heart cells from rats, 4 to 6 days old, stimulated and prolonged beating. Protein synthesis was slowed down in the presence of steroids. Addition of steroids to cells that had stopped beating caused the reestablishiment of the beat.