Myelin Membrane: A Molecular Abnormality

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Science  17 Dec 1965:
Vol. 150, Issue 3703, pp. 1613-1614
DOI: 10.1126/science.150.3703.1613


Myelin was isolated from cerebral white matter from a patient who had died of metachromatic leukodystrophy, and its lipid composition was analyzed. Although the lipid content was nearly normal, the myelin contained a three- to fourfold excess of cerebroside sulfate and a threefold deficiency of cerebroside compared to normal myelin. The deficiency of cerebroside and the excess of cerebroside sulfate may account for defective myelination in this disease.