Lactate Dehydrogenase Isozyme Patterns of Human Platelets and Bovine Lens Fibers

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Science  24 Dec 1965:
Vol. 150, Issue 3704, pp. 1735-1737
DOI: 10.1126/science.150.3704.1735


Human platelets and bovine lens fibers contain lactate dehydrogenase-3 (LDH-3) as the predominant isozyme but only very faint traces of LDH-5. Since the platelets and lens fibers, like mature human erythrocytes, lack a nucleus, the results strengthen the case for a previously developed association between LDH-5 and the cell nucleus. These three cell types are mainly anaerobic, and therefore their isozyme patterns are incompatible with the theory that anaerobic tissues exhibit predominantly LDH-5 and aerobic tissues mainly LDH-1.