Humoral Mediation of Radiation-Induced Motivation in Parabiont Rats

Science  24 Dec 1965:
Vol. 150, Issue 3704, pp. 1747-1748
DOI: 10.1126/science.150.3704.1747


Parabiont rat pairs with a skin-vascular anastomosis were used to test for a radiation-induced transferable humoral factor which would motivate aversive conditioning in a nonirradiated (shielded) recipient. The shielded partner, by tasting saccharinflavored fluid shortly after its partner was x-irradiated (360 roentgens), was aversively conditioned to saccharin. This was interpreted as evidence for a humoral motivating factor.