Spleen as a Production Site for Erythropoietin

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Science  31 Dec 1965:
Vol. 150, Issue 3705, pp. 1831-1833
DOI: 10.1126/science.150.3705.1831


Mice treated with acellular extracts of spleen and liver show a pronounced and significant increase in blood reticulocytes. In control mice treated with saline and extracts of kidney, muscle, and liver of splenectomizedmice and rats, the number of reticulocytes remained constant in all the cases.