Thymine Addition to Ethanol: Induction by Gamma Irradiation

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Science  07 Jan 1966:
Vol. 151, Issue 3706, pp. 68-70
DOI: 10.1126/science.151.3706.68


When thymine in dilute, deaerated, aqueous solution was irradiated with γ-rays in the presence of ethanol, a high yield of products containing both the thymine and ethanol moieties was obtained. These were shown to be isomers formed by the attack of CH3CHOH radicals at the carbon No. 6 position of thymine. A similar reaction was observed with N, N'-dimethylthymine, but O,O'-dimethylthymine did not react. The reaction may be relevant to the resistance of certain cells to ionizing radiation.