Homograft Target Cells: Contact Destruction in vitro by Immune Macrophages

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Science  07 Jan 1966:
Vol. 151, Issue 3706, pp. 97-99
DOI: 10.1126/science.151.3706.97


Specific adherence of immune macrophages to monolayers of target cells is a passive phenomenon which represents only the first step in the mutually destructive interaction of immune macrophages and target cells. A specific hemagglutinin, responsible for specific adherence, was eluted from well-washed immune macrophages by heat treatment. The nature of the events in the interaction subsequent to adherence are unknown, but apparently demand the biosynthetic activities of the immune macrophage.