Spontaneous Mutation Rates at Five Coat-Color Loci in Mice

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Science  14 Jan 1966:
Vol. 151, Issue 3707, pp. 205-206
DOI: 10.1126/science.151.3707.205


Examination of 1.5 million mice yielded natural mutation rates estimnated from 5.2 million gene reproductions at five specific coat-color loci. The average rates were 11.1 x 10-6 for forward mutations and 2.7 x 10-6 for reverse mutations. Differences between the frequencies of mutations at the individual loci were evident.