Anticholinesterase-Induced Amnesia and Its Temporal Aspects

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Science  14 Jan 1966:
Vol. 151, Issue 3707, pp. 221-223
DOI: 10.1126/science.151.3707.221


Injection of the anticholinesterase drug diisopropyl fluorophosphate into the hippocampi of rats, 30 minutes after escape learning, produces partial amnesia with full recovery 5 days after injection. No such amnesia is produced if the injection takes place 3 days after learning. However, with injections 5 days after learning there is again an effect, and at 14 days amnesia is complete though no normal forgetting occurs within this period.