Reports

Chloroquine: Mode of Action

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Science  21 Jan 1966:
Vol. 151, Issue 3708, pp. 347-349
DOI: 10.1126/science.151.3708.347

Abstract

The drug chloroquine is bactericidal for Bacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.

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