Hyperbaric Oxygenation: The Eye as a Limiting Factor

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Science  28 Jan 1966:
Vol. 151, Issue 3709, pp. 466-468
DOI: 10.1126/science.151.3709.466


In dogs exposed to 100 percent oxygen at 3 atmospheres absolute pressure for more than 4 hours, a characteristic retinal lesion, manifested as the cytoid-body change, occurs. The selectivity of this injury suggests that the eye may be used as a sensitive indicator and as a site for study of oxygen toxicity. The cytoid body, an entity of disputed genesis, was produced experimentally for the first time.