Sialic Acid Binding Sites: Role in Hemagglutination by Mycoplasma gallisepticum

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Science  04 Feb 1966:
Vol. 151, Issue 3710, pp. 590-591
DOI: 10.1126/science.151.3710.590


Hemagglutination of turkey erythrocytes by Mycoplasma gallisepticum was inhibited by mucoproteins containing sialic acid, by sialic acid itself, and by treatment of the erythrocytes with neuraminidase. Neuraminidase treatment of the mucoprotein-rich inhibitors reduced or abolished their inhibitory activity. The findings indicate that sialic acid on the erythrocyte surface provides binding sites for Mycoplasma gallisepticum.