Puromycin Effect on Successive Phases of Memory Storage

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Science  04 Feb 1966:
Vol. 151, Issue 3710, pp. 594-595
DOI: 10.1126/science.151.3710.594


Mice injected bitemporally with puromycin 5 hours before training learned to escape or to avoid shock by choosing the correct limb of a Y-maze. When retested 15 minutes after training they had normal retention. In the ensuing 2¾ hours the animals injected with puromycin, unlike the controls, showed a progressive decrease of savings to less than 7 percent.