Morphogenesis in Trichoderma: Suppression of Photoinduction by 5-Fluorouracil

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Science  11 Feb 1966:
Vol. 151, Issue 3711, pp. 696-698
DOI: 10.1126/science.151.3711.696


Sporulation in the fungus Trichoderma viride is inducible with a short light pulse. 5-Fluorouracil applied prior to photoinduction and removed thereafter suppressed sporulation without greatly aflecting growth. This compound also halved the rate of incorporation of uracil-C14 into RNA but did not change the ratio of uridylic to cytidylic acid. The effect of 5-fluorouracil was counteracted by uracil but not by thymidine. This supports the hypothesis that 5-fluorouracil affects RNA rather than DNA.