Magnesium Pemoline: Enhancement of Brain RNA Polymerases

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Science  11 Feb 1966:
Vol. 151, Issue 3711, pp. 702-703
DOI: 10.1126/science.151.3711.702


The stimulation by magnesium pemoline of systems that synthesize brain nucleic acid was studied in vivo and in vitro. There are differential effects between true RNA polymerase and pseudo-RNA polymerase. The selective stimulation of true RNA polymerase by magnesium pemoline was not observed with stimulants of the central nervous system and psychotropic agents.