Reports

Magnesium Pemoline: Enhancement of Brain RNA Polymerases

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Science  11 Feb 1966:
Vol. 151, Issue 3711, pp. 702-703
DOI: 10.1126/science.151.3711.702

Abstract

The stimulation by magnesium pemoline of systems that synthesize brain nucleic acid was studied in vivo and in vitro. There are differential effects between true RNA polymerase and pseudo-RNA polymerase. The selective stimulation of true RNA polymerase by magnesium pemoline was not observed with stimulants of the central nervous system and psychotropic agents.