Primary-Type Antibody Response in vitro

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Science  04 Mar 1966:
Vol. 151, Issue 3714, pp. 1096-1098
DOI: 10.1126/science.151.3714.1096


Organ cultures of lymph nodes obtained from nonimmunized rabbits were incubated with bacteriophage d, X174; as a result, 19S antibody was produced first, and then 7S antibody. Differences between this response and the secondary response to d? X174 induced in vitro suggest that the foriiier is a primary response.