Thiosemicarbazide Injection Followed by Electric Shock Increases Resistance to Stress in Rats

See allHide authors and affiliations

Science  04 Mar 1966:
Vol. 151, Issue 3714, pp. 1101-1102
DOI: 10.1126/science.151.3714.1101


Adult rats that had been raised with a minimum of stimulation were injected with thiosemicarbazide, a drug that lowers y-aminobutyric acid concentrations. Fifteen minutes later the animals were given 30 mild electric shocks over a half-hour period. Two. weeks later they were tested for their resistance to gastric ulceration induced by immobilization. The experimental animals showed a much greater resistance to stress than did the appropriate control groups. A replication confirmed the results of the first study.