Low-Molecular-Weight Proteins Related to Bence Jones Proteins in Multiple Myeloma

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Science  11 Mar 1966:
Vol. 151, Issue 3715, pp. 1237-1239
DOI: 10.1126/science.151.3715.1237


Urinary proteins distinct from Bence Jones proteins, but sharing antigenic determinants, were found in the urine of a number of patients with multiple myeloma. These components were smaller in size and antigenically deficient compared with Bence Jones proteins. They were best detected with antiserums to the homologous Bence Jones proteins and, in some cases, were related to the variable portion of the Bence Jones protein molecule.