Immunological Competence: Alteration by Whole Body X-Irradiation and Shielding of Selected Lymphoid Tissues

Science  18 Mar 1966:
Vol. 151, Issue 3716, pp. 1395-1397
DOI: 10.1126/science.151.3716.1395


The spleen and thymus of 6-week-old mice contain similar numbers of lymphoid cells. A lethal dose of x-irradiation given to animials whose thymus, midgut, or hindlimbs were shielded at the same time resulted in permanent acceptance of allografts, while a similar dose given to spleen-shielded mice so irradiated resulted in a normal rejection pattern. The return of immunological competence was related to the state of the lymphoid organs with different types of shielding.