Aflatoxin B1: Binding to DNA in vitro and Alteration of RNA Metabolism in vivo

Science  25 Mar 1966:
Vol. 151, Issue 3717, pp. 1539-1541
DOI: 10.1126/science.151.3717.1539


Aflatoxin B1 binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B1 may be direct results of the affinity of this agent for DNA.