Tetraethylammonium and Tetrodotoxin: Effects on Cochlear Potentials

Science  25 Mar 1966:
Vol. 151, Issue 3717, pp. 1544-1545
DOI: 10.1126/science.151.3717.1544


Tetraethylammonium chloride, which is believed to decrease potassium conductance, and tetrodotoxin, which apparently decreases sodium conductance in nerve fibers, were introduced iontophoretically into the organ of Corti or the scala media of guinea pig cochlea. The former depressed the direct-current endocochlear potential and also the alternating-current cochlear microphonics (the receptor potential of the ear), but tetrodotoxin was ineffective except on the nerve impulses.