Lithium's Failure to Replace Sodium in Mammalian Sympathetic Ganglia

Science  01 Apr 1966:
Vol. 152, Issue 3718, pp. 85-87
DOI: 10.1126/science.152.3718.85


Ganglionic responses to electrical stimulation, acetylcholine, and potassium ions were studied in superior cervical ganglia of. cats perfused with media containing lithium chloride instead of sodium chloride. In lithium-Locke, ganglionic transmission and depolarization evoked by acetylcholine were blocked completely but reversibly, while the depolarization produced by potassium ions was unaltered.