Glucose-6-Phosphatase in Tubular Endoplasmic Reticulum of Hepatocytes

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Science  15 Apr 1966:
Vol. 152, Issue 3720, pp. 352-354
DOI: 10.1126/science.152.3720.352


The histochemical localization of glucose-6-phosphatase activity in neonatal mouse liver was studied under electron microscopy. The activity was demonstrated in the tubular endoplasmic reticulum, which pervades the glycogen areas of the cell during glycogenolysis. Activity was also demonstrated in the nuclear envelope and ergastoplasm.