Erythropoietin: Hypothesis of Action Tested by Analog Computer

See allHide authors and affiliations

Science  15 Apr 1966:
Vol. 152, Issue 3720, pp. 367-370
DOI: 10.1126/science.152.3720.367


The action of erythropoietin on the pool of undifferentiated bone marrow cells has been examined with the aid of a model tested with an analog computer. The model is consistent with reported experimental results. The essential aspects of the action are (i) the effect is exerted during the S phase of the cell's cycle; (ii) " effective " erythropoietin is present in the cell only during G1 and part of S; and, (iii) hormone molecules survive in the cell for only a limited time in effective form and require a certain time to assume this form.