Radiosensitization of X Chromosome of Chinese Hamster Cells Related to Incorporation of 5-Bromodeoxyuridine

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Science  22 Apr 1966:
Vol. 152, Issue 3721, pp. 519-521
DOI: 10.1126/science.152.3721.519


Selective incorporation of 5-bromodeoxyuridine into the late replicating arm of the X chromosome of Chinese hamister cells cultured in vitro caused a selective radiosensization of the arm to ionizing radiation. Radiation damage was observed as chromosomal aberrations, and incorporation was studied by using tritiated 5-bromodeoxyuridine.