Nicotinamide-Adenine Dinucleotide in Tubercle Bacilli Exposed to Isoniazid

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Science  22 Apr 1966:
Vol. 152, Issue 3721, pp. 525-526
DOI: 10.1126/science.152.3721.525


There is a decrease in the content of nicotinamide-adenine dinucleotide of tubercle bacilli grown in the presence of isoniazid. In extracts of tubercle bacilli, the activity of nicotinamide-adenine dinucleotidase is nil or very small; after incubation with the drug the enzyme becomes active. Isoniazid also increases the activity of the enzyme after it is partially activated by heating. There may be a correlation between the capacity of isoniazid to activate the enzyme and the decrease in the dinucleotide content of the tubercle bacilli.